Literature summary extracted from

Sylman, J.; Daalkhaijav, U.; Zhang, Y.; Gray, E.; Farhang, P.; Chu, T.; Zilberman-Rudenko, J.; Puy, C.; Tucker, E.; Smith, S.; Morrissey, J.; Walker, T.; Nan, X.; Gruber, A.; McCarty, O.
Differential roles for the coagulation factors XI and XII in regulating the physical biology of fibrin (2017), Ann. Biomed. Eng., 45, 1328-1340 .

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.21.38	additional information	the enzyme is activated when blood is exposed to negatively-charged foreign surfaces or molecules such as RNA, DNA, misfolded proteins, and polyphosphates	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.38	corn trypsin inhibitor	-	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.21.38	factor XI + H2O	Homo sapiens	-	factor XIa + ?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.38	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.38	factor XI + H2O	-	Homo sapiens	factor XIa + ?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.38	FXIIa	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
3.4.21.38	malfunction	factor XII inhibition decreases the fibrin formation (5fold) and fibrin density, and increases the fibrinolysis rate when fibrin formation is initiated via the contact activation pathway with long-chain polyphosphate polyP	Homo sapiens

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Release 2023.1 (January 2023)